Dose-Dependent Adverse Effects of Salinomycin on Male Reproductive Organs and Fertility in Mice

Dose-Dependent Adverse Effects of Salinomycin on Male Reproductive Organs and Fertility in Mice

Salinomycin is used as an antibiotic in animal husbandry. Its implication in cancer therapy has recently been proposed. Present study evaluated the toxic effects of Salinomycin on male reproductive system of mice. Doses of 1, 3 or 5 mg/kg of Salinomycin were administered daily for 28 days. Half of the mice were sacrificed after 24 h of the last treatment and other half were sacrificed 28 days a...

Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole

study on the reproductive organs and fertility of the male mice following administration of metronidazole

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Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole

BACKGROUND : Metronidazole (MTZ) is commonly used as an antibacterial and antiprotozoal drug. Various doses of MTZ have been reported to inhibit spermatogenic activity and sperm indices. MATERIALS AND METHODS In this experimental study, dose-dependent effects of MTZ on the structural and functional integrity of the testis and accessory reproductive organs have been investigated. Adult male mi...

effects of glycowithanolides on lipid peroxidation and lipofuscinogenesis in male reproductive organs of mice

background: glycowithanolides (withaferin a), is one of the main withanolides active principle isolated from plant withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties. objective: in the present investigation, antioxidant activity of active principles of withania somnifera was tested against d-galactose induced oxidative stress i...